Project 1 for NESC4177 (Theoretical Neuroscience), Fall 2006

Short-term neuronal memory with h-currents

A Hodkin-Huxley type neuron respond to sufficently large inputs but seases firing when this input is removed. Thus, this neuron does not provide mechanisms for a short term memory by sustained actitivty on a single neuron level. In this project you should modify the Hodkin-Huxley model with a voltage-dependent current that keeps the neuron firing when it was active before. This can be achieved by a depolarizing current that is triggered by the hyperpolarization of a previous spike. Implement such an h-current and study the behavious of this model with a varying conductance parameter in this model.

Some related papers with reviews are Fransen and Lueti&McCormick. Write up your observations in a short conference-style paper with no more than 4 pages.

Deadline: Tuesday October 31/06